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Trigeminal Nerve Stimulation (TNS) is a novel medical treatment in which mild electrical signals stimulate branches of the trigeminal nerve (the largest cranial nerve) in order to modulate the activity of targeted brain regions. NeuroSigma is developing two embodiments of TNS: eTNSTM (TNS with external electrodes and an external pulse generator) and sTNSTM (subcutaneous electrodes and implantable pulse generator).